{"id":809,"date":"2010-04-21T11:33:16","date_gmt":"2010-04-21T02:33:16","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=809"},"modified":"2015-08-07T11:33:36","modified_gmt":"2015-08-07T02:33:36","slug":"%ef%bd%9e%e3%83%a9%e3%82%af%e3%83%8a%e6%a2%97%e5%a1%9e%e3%81%ae2%e6%ac%a1%e4%ba%88%e9%98%b2%e3%81%ab%e6%9c%89%e5%8a%b9%e3%81%aa%e8%96%ac%e5%89%a4%e3%81%af%e4%bd%95%e3%81%8b%ef%bc%9f%ef%bd%9e","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=809","title":{"rendered":"\uff5e\u30e9\u30af\u30ca\u6897\u585e\u306e2\u6b21\u4e88\u9632\u306b\u6709\u52b9\u306a\u85ac\u5264\u306f\u4f55\u304b\uff1f\uff5e"},"content":{"rendered":"<p>\u3010\u6587\u732e\u3011<br \/>\nGotoh F, et al.: Cilostazol stroke prevention study: a placebo-cintrolled double-blind trial for secondary prevention of cerebral infarction J Stroke Cerebrovasc Dis. 9 (4): 147-57, 2000.<\/p>\n<p>\u3010\u8981\u7d04\u3011<br \/>\n\uff08\u3053\u306e\u7814\u7a76\u306e\u76ee\u7684\uff09<br \/>\n\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u591a\u65bd\u8a2d\u3001\u7121\u4f5c\u70ba\u3001\u30d7\u30e9\u30bb\u30dc\u6bd4\u8f03\u5bfe\u7167\u3001\u4e8c\u91cd\u76f2\u691c\u81e8\u5e8a\u8a66\u9a13\u3092\u7528\u3044\u3066\u3001\u8133\u6897\u585e\u306e\u518d\u767a\u306b\u304a\u3051\u308b\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb\u306e\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002<br \/>\n\uff08\u3053\u306e\u6587\u732e\u306ePECO\uff09<br \/>\nP\uff1a\u8133\u6897\u585e\u767a\u75c7\u5f8c1\uff5e6\u304b\u6708\u4ee5\u5185\u306e\u60a3\u8005<br \/>\nE\uff1a\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb100mg1\u65e52\u56de\u6295\u4e0e<br \/>\nC\uff1a\u30d7\u30e9\u30bb\u30dc<br \/>\nO\uff1a\u8133\u6897\u585e\u306e\u518d\u767a\u3092\u4e88\u9632\u3067\u304d\u308b\u304b\uff1f<br \/>\n\uff08\u65b9\u6cd5\uff09<br \/>\n\u671f\u9593\u306f1992\u5e744\u6708\uff5e1996\u5e743\u6708\u306b\u304a\u3044\u3066\u8133\u6897\u585e\u767a\u75c7\u5f8c1\uff5e6\u30f6\u6708\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002<br \/>\n\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb100mg 1\u65e52\u56de\u6295\u4e0e\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u306b\u3001\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002<br \/>\nPrimary endpoint\u306f\u8133\u6897\u585e\u306e\u518d\u767a\u3002\u6700\u7d42\u7684\u306b\u30011095\u4eba\u306e\u60a3\u8005\u304c\u767b\u9332\u3002\u3046\u30611052\u4eba\u304c\u6b8b\u308a\u3001\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb\u6295\u4e0e\u7fa4526\u4eba\u3001\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4526\u4eba\u306b\u5272\u308a\u632f\u3089\u308c\u305f\u3002<br \/>\nBase line\u306b\u6709\u610f\u306a\u9055\u3044\u306f\u306a\u304b\u3063\u305f\u3002\u8133\u6897\u585e\u306e\u7a2e\u985e\u3067\u306f\u3001\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb\u6295\u4e0e\u7fa4\uff0f\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u3067\u3001\u30e9\u30af\u30ca\u6897\u585e\u304c75.0\uff05\uff0f73.8\uff05\u3068\u6700\u3082\u591a\u3044\u5272\u5408\u3092\u5360\u3081 \u305f\u3002\u5185\u670d\u671f\u9593\u306f632.2\u00b1467.7\u65e5\uff0f695.1\u00b1456.3\u65e5\u3067\u3042\u3063\u305f\u3002\u6700\u7d42\u7684\u306b\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u901a\u308a\u6295\u85ac\u3092\u53d7\u3051\u305f\u7d9a\u3051\u305f\u60a3\u8005\u306f\u3001\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb\u6295\u4e0e\u7fa4 \u3067250\u4eba\uff08\u8ffd\u8de1\u7387250\/544=46\uff05\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u3067\u306f279\u4eba\uff08\u8ffd\u8de1\u7387279\/548\uff1d50.9\uff05\uff09\u3067\u3042\u3063\u305f\u3002<br \/>\n\uff08\u7d50\u679c\uff09<br \/>\n\uff08evaluable population\u8a55\u4fa1\u53ef\u80fd\u306a\u96c6\u56e3\uff091052\u4eba\u306e\u4e2d\u3067121\u4eba\u304c\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u751f\u3058\u305f\u3002<br \/>\n\u975e\u81f4\u6b7b\u7684\u306a\u3082\u306e\u306f48\u4eba\uff0f69\u4eba\u3001\u81f4\u6b7b\u7684\u306a\u3082\u306e\u306f0\u4eba\uff0f4\u4eba\u3067\u3042\u3063\u305f\u3002<br \/>\n\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb\u6295\u4e0e\u7fa4\u3067\u3082\u8133\u51fa\u8840\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u306a\u304b\u3063\u305f\u3002<br \/>\n\u8133 \u6897\u585e\u304c\u518d\u767a\uff08Primary endpoint\uff09\u3057\u305f\u60a3\u8005\u306f\u3001\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb\u6295\u4e0e\u7fa4\u3067\u306f30\u4eba\uff0f889.6\u4eba\u5e74\u3067\uff083.37\uff05\uff0f\u5e74\uff09\u3042\u3063\u305f\u3002\u4e00\u65b9\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f57\u4eba\uff0f986.0\u4eba\u5e74 \uff085.78\uff05\uff0f\u5e74\uff09\u3067\u3042\u308a\u3001RRR41.7% [CI],9.2% to 62.5%\uff08P=.0150\uff09\u3001NNT41.5\u3067\u3042\u3063\u305f\u3002<br \/>\n\u307e\u305f\u30011067\u4eba\u306eITT\u89e3\u6790\u3067\u3082RRR42.3% [CI],10.3% to 62.9%\uff08P=.0127\uff09\u3067\u3042\u3063\u305f\u3002<br \/>\n\u3055 \u3089\u306b\u3001subgroup\u89e3\u6790\u3067\u8133\u6897\u585e\u306e\u30bf\u30a4\u30d7\u5225\u306b\u304a\u3051\u308b\u30e9\u30af\u30ca\u6897\u585e\u306e\u767a\u751f\u306f\u30b7\u30ed\u30b9\u30bf\u30be\u30fc\u30eb\u6295\u4e0e\u7fa4\u306720\u4eba\uff0f673.8\u4eba\u5e74\uff082.97\uff05\uff0f\u5e74\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u6295 \u4e0e\u7fa4\u306739\u4eba\uff0f743.4\u4eba\u5e74\uff085.25\uff05\uff0f\u5e74\uff09\u3067\u3042\u308a\u3001RRR43.4%[CI],3.0% to 67.0%\uff08P=.0373\uff09\u3001NNT43.9\u3067\u3042\u3063\u305f\u3002<\/p>\n<p>\u3010\u958b\u50ac\u65e5\u3011<br \/>\n\uff12\uff10\uff11\uff10\u5e74\uff14\u6708\uff12\uff11\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u6587\u732e\u3011 Gotoh F, et al.: Cilostazol stroke prevention study: a placebo-cintrolled double-blind trial for secondar &hellip; <a href=\"https:\/\/www.hcfm.jp\/journal\/?p=809\" class=\"more-link\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"screen-reader-text\">\uff5e\u30e9\u30af\u30ca\u6897\u585e\u306e2\u6b21\u4e88\u9632\u306b\u6709\u52b9\u306a\u85ac\u5264\u306f\u4f55\u304b\uff1f\uff5e<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-809","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=809"}],"version-history":[{"count":1,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/809\/revisions"}],"predecessor-version":[{"id":810,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/809\/revisions\/810"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}