{"id":889,"date":"2015-10-22T16:11:51","date_gmt":"2015-10-22T07:11:51","guid":{"rendered":"http:\/\/www.hcfm.jp\/journal\/?p=889"},"modified":"2015-10-22T16:11:51","modified_gmt":"2015-10-22T07:11:51","slug":"als%e6%82%a3%e8%80%85%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%83%a9%e3%82%b8%e3%82%ab%e3%83%83%e3%83%88%e3%81%ae%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%a8%e5%ae%89%e5%85%a8%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.hcfm.jp\/journal\/?p=889","title":{"rendered":"ALS\u60a3\u8005\u306b\u304a\u3051\u308b\u30e9\u30b8\u30ab\u30c3\u30c8\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027"},"content":{"rendered":"

\u2015\u6587\u732e\u540d\u2015
\nKOJI ABE, YASUTO ITOYAMA. Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration,2014;15:610-617<\/p>\n

\u2015\u8981\u7d04\u2015
\n\u3010\u76ee\u7684\u3011
\n\u3000ALS\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u4e8c\u91cd\u76f2\u691c\u4e26\u884c\u7fa4\u9593\u6bd4\u8f03\u6cd5\u306b\u3088\u308a\u3001\u30e9\u30b8\u30ab\u30c3\u30c860mg\u30926\u30af\u30fc\u30eb\u6295\u4e0e\u3057\u305f\u3068\u304d\u306e\u6709\u52b9\u6027\u53ca\u3073\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u3001\u30d7\u30e9\u30bb\u30dc\u3092\u5bfe\u7167\u3068\u3057\u3066\u691c\u8a0e\u3057\u305f\u3002<\/p>\n

\u3010\u5bfe\u8c61\u3011
\n\u3000ALS\u60a3\u8005205\u540d\uff08\u30e9\u30b8\u30ab\u30c3\u30c8\u7fa4101\u540d\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4104\u540d\uff09
\n\u3000\u9078\u629e\u57fa\u6e96\u306fEl Escorial \u6539\u8a02Airlie House\u8a3a\u65ad\u57fa\u6e96\u306e\u3046\u3061\u3001\u300cDefinite\u300d\u300cProbable\u300d\u300cProbable-laboratory-\u3000supported\u300d\u3001ALS\u91cd\u75c7\u5ea6\u5206\u96e2\u306e\u3046\u3061\u30011\uff0c2\u5ea6\u3001\u52aa\u529b\u6027\u80ba\u6d3b\u91cf\u306f70%\u4ee5\u4e0a\u3001\u7f79\u75c5\u671f\u9593\u306f3\u5e74\u4ee5\u5185\u3001\u524d\u89b3\u5bdf\u671f12\u9031\u9593\u306eALSFRS-R\u30b9\u30b3\u30a2\u306e\u5909\u5316\u304c-1\uff5e-4\u306e\u60a3\u8005\u3002<\/p>\n

\u3010\u65b9\u6cd5\u3011
\n\u3000\u6295\u4e0e\u958b\u59cb12\u9031\u524d\u306e\u524d\u89b3\u5bdf\u671f\u306e\u5f8c\u3001\u88ab\u9a13\u8005\u3092\u30e9\u30b8\u30ab\u30c3\u30c8\u7fa4\u53c8\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u4e8c\u91cd\u76f2\u691c\u4e0b\u3067\u5272\u4ed8\u3051\u3001\u70b9\u6ef4\u9759\u8108\u5185\u6295\u4e0e\u30926\u30af\u30fc\u30eb\u884c\u3063\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306fALSFRS-R\u30b9\u30b3\u30a2\u3001\u4e8c\u6b21\u7684\u306a\u8a55\u4fa1\u9805\u76ee\u306fFVC\u3001\u624b\u9996\u30fb\u6307\u5148\u306e\u529b\u5909\u5316\u3001Modified Norris Scale score\u3001ALSAQ-40\u3002<\/p>\n

\u3010\u7d50\u679c\u3011
\n\u3000\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308bALSFRS-R\u30b9\u30b3\u30a2\u306e6\u30af\u30fc\u30eb\u300124\u9031\u9593\u306e\u5909\u5316\u91cf\u306f\u30e9\u30b8\u30ab\u30c3\u30c8\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u6295\u4e0e\u7fa4\u9593\u5dee\u306f0.65\u00b10.78\u3067\u3001p\u5024\u306f0.4108\u3067\u3042\u308a\u3001\u6709\u610f\u306a\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002%FVC\u3001\u624b\u9996\u306e\u529b\u3001Modified Norris Scale score\u3001ALSAQ-40\u306b\u3064\u3044\u3066\u3082\u6709\u610f\u306a\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002\u6307\u5148\u306e\u529b\u306b\u3064\u3044\u3066\u306f\u7e70\u308a\u8fd4\u3057\u306e\u5206\u6563\u5206\u6790\u306b\u304a\u3044\u3066\u6709\u610f\u5dee\u3092\u8a8d\u3081\u305f\u3002<\/p>\n

\u3010\u7d50\u8ad6\u3011
\n\u3000\u30e9\u30b8\u30ab\u30c3\u30c8\u6295\u4e0e\u306b\u3088\u3063\u3066ALSFRS-R\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u3079\u6e1b\u5c11\u306f\u5c11\u306a\u304b\u3063\u305f\u304cALS\u306b\u304a\u3051\u308b\u52b9\u679c\u306f\u793a\u3055\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n

\u3053\u306e\u307e\u307e\u3060\u3068\u306a\u305c\u30e9\u30b8\u30ab\u30c3\u30c8\u304c\u4fdd\u967a\u9069\u5fdc\u306b\u306a\u3063\u305f\u304b\u306f\u4e0d\u660e\u3059\u304e\u308b\u30fb\u30fb\u30fb
\n\u2193
\n\u8ffd\u52a0
\n\u4eca\u56de\u306e\u8a66\u9a13\uff08\u691c\u8a3c\u8a66\u9a13\u30001\u56de\u76ee\u3000\u7b2c\u2162\u76f8\uff09
\n\"\u698e\u539f\u5148\u751f\u2460.jpg\"<\/a><\/p>\n

\u3000\u4e3b\u8981\u306a\u8a55\u4fa1\u9805\u76ee\u3067\u6709\u610f\u5dee\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u304c\u8a3a\u65ad\u304c\u78ba\u5b9f\u306a\u3082\u306e\u3084\u91cd\u75c7\u5ea6\u304c\u4f4e\u3044\u307b\u3046\u304c\u5dee\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u305f\u3081\u306b\u305d\u306e\u5f8c\u306e\u8a66\u9a13\uff08\u691c\u8a3c\u8a66\u9a132\u56de\u76ee\u3000\u7b2c\u2162\u76f8\uff09\u304c\u884c\u308f\u308c\u305f\u3002
\n\"\u698e\u539f\u5148\u751f\u2461\"<\/a><\/p>\n

\u30002\u8a66\u9a13\u3068\u3082\u91cd\u75c7\u5ea61\u30012\u5ea6\u306e\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3067\u306f\u3042\u3063\u305f\u304c\u3001\u3053\u306e\u57fa\u6e96\u304c\u66d6\u6627\u3060\u3063\u305f\u305f\u3081\u3001\u691c\u8a3c\u7684\u8a66\u9a131\u56de\u76ee\u306f\u91cd\u75c7\u5ea6\u5206\u985e3\u5ea6\u306b\u8fd1\u3044\u91cd\u75c7\u306e\u60a3\u8005\u3055\u3093\u304c\u591a\u6570\u30a8\u30f3\u30c8\u30ea\u30fc\u3055\u308c\u3001\u6709\u52b9\u6027\u3092\u78ba\u8a8d\u3067\u304d\u306a\u304b\u3063\u305f\u4e00\u56e0\u3068\u306a\u3063\u305f\u3068\u7d50\u8ad6\u3002\u305d\u306e\u305f\u3081\u3001\u691c\u8a3c\u7684\u8a66\u9a132\u56de\u76ee\u306fALSFRS-R\u30b9\u30b3\u30a2\u304c\u300c\u5168\u9805\u76ee2\u70b9\u4ee5\u4e0a\u300d\u3068\u3044\u3046\u57fa\u6e96\u3092\u8a2d\u3051\u3001\u53b3\u683c\u306b\u8efd\u75c7\u306e\u60a3\u8005\u3055\u3093\u3092\u5b9a\u7fa9\u3057\u3001\u3055\u3089\u306b\u3001\u691c\u8a3c\u7684\u8a66\u9a132\u56de\u76ee\u306f\u52aa\u529b\u6027\u80ba\u6d3b\u91cf80%\u4ee5\u4e0a\u306e\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u8efd\u75c7\u306e\u60a3\u8005\u3055\u3093\u3092\u9078\u629e\u3057\u30011\u56de\u76ee\u3068\u540c\u69d8\u306e\u8a66\u9a13\u3092\u5b9f\u65bd\u3057\u305f\u3002
\n\u3000\u305d\u306e\u7d50\u679c\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306eALSFRS-R\u30b9\u30b3\u30a2\u306e\u4f4e\u4e0b\u306f\u30e9\u30b8\u30ab\u30c3\u30c8\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u6295\u4e0e\u7fa4\u9593\u5dee\u30672.49\u00b10.76\u3067\u3001p\u5024\u306f0.0013\u6709\u610f\u306a\u4f4e\u4e0b\u3092\u8a8d\u3081\u30016\u304b\u6708\u6295\u4e0e\u6642\u70b9\u3067\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u306e4\u304b\u6708\u306e\u30b9\u30b3\u30a2\u3068\u540c\u7a0b\u5ea6\u3060\u3063\u305f\u3002ALSAQ-40\u30b9\u30b3\u30a2\u306e6\u30af\u30fc\u30eb\u300124\u9031\u9593\u306e\u5909\u5316\u91cf\u306f\u3001\u30e9\u30b8\u30ab\u30c3\u30c8\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u6295\u4e0e\u7fa4\u9593\u5dee\u3067-8.79\u00b14.03\u3067\u3001p\u5024\u306f0.0309\u3067\u3042\u308a\u3001ALSAQ-40\u30b9\u30b3\u30a2\u306e\u4e0a\u6607\u306f\u6709\u610f\u306a\u5dee\u3092\u8a8d\u3081\u305f\u3002<\/p>\n

\u8cc7\u6599
\nALS\u91cd\u75c7\u5ea6\u5206\u985e
\n\"\u698e\u539f\u5148\u751f\u2462\"<\/a><\/p>\n

ALS\u6a5f\u80fd\u8a55\u4fa1\u30b9\u30b1\u30fc\u30eb\u6539\u8a02\u7248\uff08ALSFRS-R: The revised ALS Functional Rating Scale\uff09
\n\u3000\u60a3\u8005\u3078\u306e\u805e\u304d\u53d6\u308a\u53ca\u3073\u5b9f\u969b\u306e\u52d5\u4f5c\u3092\u89b3\u5bdf\u3057\u3066\u63a1\u70b9\u3092\u884c\u3046\u3002\u4ee5\u4e0b\u306e12\u9805\u76ee\u306b\u3064\u3044\u3066\u3001\u5404\u9805\u76ee\u30920\uff5e4\u306e5\u6bb5\u968e\u3067\u63a1\u70b9\u3059\u308b\u3002
\n\"\u698e\u539f\u5148\u751f\u2463\"<\/a><\/p>\n

\u25cfALSAQ-40
\n\u3000ALS\u306b\u7279\u7570\u7684\u306aQOL\u5c3a\u5ea6
\n\u30005\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5272\u308a\u632f\u3089\u308c\u305f40\u9805\u76ee\u306e\u8cea\u554f\u304b\u3089\u306a\u308b\u3002
\n\u3000\uff1c5\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\uff1e
\n\u3000\u3000\u300c\u30d5\u30a3\u30b8\u30ab\u30eb\u306a\u53ef\u52d5\u6027\uff0810\u554f\uff09\u300d\u3001\u300cADL\u3068\u81ea\u7acb\u6027\uff0810\u554f\uff09\u300d\u3001\u300c\u98df\u3079\u3066\u98f2\u3080\u3053\u3068\uff083\u554f\uff09\u300d\u3001\u300c\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\uff087\u554f\uff09\u300d\u3001
\n\u3000\u3000\u300c\u611f\u60c5\u4f5c\u7528\uff0810\u554f\uff09\u300d
\n\u3000\u5404\u8cea\u554f\u306b\u5bfe\u3057\u88ab\u9a13\u8005\u304c1\uff5e5\u70b9\u3067\u56de\u7b54\u3057\u3001\u5408\u8a08\u30b9\u30b3\u30a2\u3067\u8a55\u4fa1\u3092\u884c\u3046\u3002\u30b9\u30b3\u30a2\u304c\u5927\u304d\u3044\u307b\u3069\u3001QOL\u4f4e\u4e0b\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u2015\u8003\u5bdf\u3068\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u2015
\n\u3000\u4eca\u56de\u8aad\u3093\u3060\u6587\u732e\u3067\u306f\u30e9\u30b8\u30ab\u30c3\u30c8\u6295\u4e0e\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u3067\u306e\u6bd4\u8f03\u3067\u306f\u6307\u5148\u306e\u529b\u4ee5\u5916\u3067\u306f\u6709\u610f\u5dee\u306f\u7121\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u9032\u3081\u305f\u7814\u7a76\u3067\u3001\u8a3a\u65ad\u304c\u78ba\u5b9f\u3067\u91cd\u75c7\u5ea6\u304c\u8efd\u5ea6\u306a\u65b9\u3067\u8a55\u4fa1\u9805\u76ee\u306b\u6709\u610f\u5dee\u304c\u51fa\u305f\u3053\u3068\u304c\u308f\u304b\u308a\u30012\u30ab\u6708\u7a0b\u5ea6\u9032\u884c\u3092\u9045\u304f\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u5177\u4f53\u7684\u306b\u3069\u306e\u90e8\u5206\u306e\u70b9\u6570\u306b\u5dee\u304c\u51fa\u305f\u306e\u304b\u306a\u3069\u306b\u3064\u3044\u3066\u306f\u308f\u304b\u3089\u306a\u304b\u3063\u305f\u305f\u3081\u6d88\u5316\u4e0d\u826f\u306a\u611f\u3058\u306f\u6b8b\u3063\u3066\u3044\u308b\u3002\u73fe\u5728MFC\u3067\u30e9\u30b8\u30ab\u30c3\u30c8\u6295\u4e0e\u3057\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u306e\u91cd\u75c7\u5ea6\u306f1\uff5e3\u5ea6\u306e\u60a3\u8005\u3055\u3093\u3067\u3042\u308a\u30013\u5ea6\u306e\u60a3\u8005\u3055\u3093\u306b\u306f\u3042\u307e\u308a\u52b9\u679c\u306f\u306a\u3044\u306e\u304b\u3082\u3057\u308c\u306a\u3044\u3002\u305f\u3060ALS\u3068\u3044\u3046\u6cbb\u7652\u304c\u671b\u3081\u306a\u3044\u75be\u60a3\u3067\u4fdd\u967a\u9069\u5fdc\u304c\u901a\u3063\u305f\u65b0\u85ac\u3067\u3042\u308a\u91cd\u75c7\u5ea6\u3067\u9069\u5fdc\u304c\u6c7a\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u60a3\u8005\u3055\u3093\u304c\u6cbb\u7642\u3092\u671b\u3080\u3053\u3068\u306f\u975e\u5e38\u306b\u7406\u89e3\u3067\u304d\u308b\u3002\u4eca\u5f8c\u3082ALS\u60a3\u8005\u3055\u3093\u306f\u8a2a\u554f\u8a3a\u7642\u3067\u95a2\u308f\u3063\u3066\u3044\u304f\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u308b\u305f\u3081\u3001\u30e9\u30b8\u30ab\u30c3\u30c8\u306e\u9650\u5b9a\u7684\u306a\u52b9\u679c\u306a\u3069\u3092\u533b\u7642\u8005\u5074\u304c\u8a8d\u8b58\u3057\u306a\u304c\u3089\u60a3\u8005\u3055\u3093\u306b\u5bc4\u308a\u6dfb\u3063\u3066\u3044\u304f\u3053\u3068\u304c\u5927\u5207\u3060\u3068\u601d\u3046\u3002<\/p>\n

\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u30dd\u30a4\u30f3\u30c8
\n\u3000\u2460ALS\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u30e9\u30b8\u30ab\u30c3\u30c8\u3092\u52e7\u3081\u307e\u3059\u304b\uff1f
\n\u3000\u2461\u52e7\u3081\u308b\u5834\u5408\u306f\u3069\u306e\u3088\u3046\u306b\u8aac\u660e\u3057\u307e\u3059\u304b\uff1f<\/p>\n

\u3010\u958b\u50ac\u65e5\u3011
\n\u30002015\u5e7410\u670821\u65e5\uff08\u6c34\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u2015\u6587\u732e\u540d\u2015 KOJI ABE, YASUTO ITOYAMA. Confirmatory double-blind, parallel-group, placebo-controlled study of efficac … \u7d9a\u304d\u3092\u8aad\u3080 ALS\u60a3\u8005\u306b\u304a\u3051\u308b\u30e9\u30b8\u30ab\u30c3\u30c8\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-889","post","type-post","status-publish","format-standard","hentry","category-17"],"_links":{"self":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/889","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=889"}],"version-history":[{"count":9,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/889\/revisions"}],"predecessor-version":[{"id":904,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=\/wp\/v2\/posts\/889\/revisions\/904"}],"wp:attachment":[{"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=889"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=889"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hcfm.jp\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}